Alzheimer's disease and Parkinson's disease : Distinct entities or extremes of a spectrum of neurodegeneration?
Identifieur interne : 003A53 ( Main/Exploration ); précédent : 003A52; suivant : 003A54Alzheimer's disease and Parkinson's disease : Distinct entities or extremes of a spectrum of neurodegeneration?
Auteurs : D. P. Perl [États-Unis] ; C. W. Olanow [États-Unis] ; D. Calne [Canada]Source :
- Annals of neurology [ 0364-5134 ] ; 1998.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
Abstract
Alzheimer's disease (AD) and Parkinson's disease (PD) are generally considered to be separate and distinct disease entities. However, a considerable amount of evidence demonstrates that these disorders share common clinical and neuropathologic features and that overlap between the two conditions is extensive. For example, a significant percentage of AD patients exhibit extrapyramidal features, and many PD patients develop dementia Similarly, at autopsy many AD patients not only exhibit the neuropathologic features of that disorder but also exhibit nigral pathology, including Lewy bodies. The vast majority of demented PD patients show widespread neurofibrillary tangles and senile plaques as well as Lewy body formation and nigral degeneration. The extent of such overlap is far greater than one would anticipate by chance alone. We argue that such overlap reflects a common pathogenic mechanism for the neurodegeneration encountered within specific vulnerable neuronal populations. Furthermore, we suggest that the current nosologic approach, which attempts to separate AD from PD, fails to properly deal with the issue of overlap and that a new classification of the neurodegenerative disorders should be considered.
Affiliations:
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Olanow</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, Mount Sinai Medical Center</s1><s2>New York, NY</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New York, NY</wicri:noRegion></affiliation></author><author><name sortKey="Calne, D" sort="Calne, D" uniqKey="Calne D" first="D." last="Calne">D. Calne</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, University of British Columbia</s1><s2>Vancouver, British Columbia</s2><s3>CAN</s3><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, British Columbia</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">98-0532234</idno><date when="1998">1998</date><idno type="stanalyst">PASCAL 98-0532234 INIST</idno><idno type="RBID">Pascal:98-0532234</idno><idno type="wicri:Area/PascalFrancis/Corpus">000D96</idno><idno type="wicri:Area/PascalFrancis/Curation">001127</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000D27</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000D27</idno><idno type="wicri:doubleKey">0364-5134:1998:Perl D:alzheimer:s:disease</idno><idno type="wicri:Area/Main/Merge">004077</idno><idno type="wicri:Area/Main/Curation">003A53</idno><idno type="wicri:Area/Main/Exploration">003A53</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Alzheimer's disease and Parkinson's disease : Distinct entities or extremes of a spectrum of neurodegeneration?</title><author><name sortKey="Perl, D P" sort="Perl, D P" uniqKey="Perl D" first="D. P." last="Perl">D. P. Perl</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Pathology [Neuropathology], Mount Sinai Medical Center</s1><s2>New York, NY</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New York, NY</wicri:noRegion></affiliation></author><author><name sortKey="Olanow, C W" sort="Olanow, C W" uniqKey="Olanow C" first="C. W." last="Olanow">C. W. Olanow</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, Mount Sinai Medical Center</s1><s2>New York, NY</s2><s3>USA</s3><sZ>2 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>New York, NY</wicri:noRegion></affiliation></author><author><name sortKey="Calne, D" sort="Calne, D" uniqKey="Calne D" first="D." last="Calne">D. Calne</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, University of British Columbia</s1><s2>Vancouver, British Columbia</s2><s3>CAN</s3><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver, British Columbia</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Annals of neurology</title><title level="j" type="abbreviated">Ann. neurol.</title><idno type="ISSN">0364-5134</idno><imprint><date when="1998">1998</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Annals of neurology</title><title level="j" type="abbreviated">Ann. neurol.</title><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer disease</term><term>Differential diagnostic</term><term>Human</term><term>Parkinson disease</term><term>Pathology</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Démence Alzheimer</term><term>Parkinson maladie</term><term>Anatomopathologie</term><term>Diagnostic différentiel</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Alzheimer's disease (AD) and Parkinson's disease (PD) are generally considered to be separate and distinct disease entities. However, a considerable amount of evidence demonstrates that these disorders share common clinical and neuropathologic features and that overlap between the two conditions is extensive. For example, a significant percentage of AD patients exhibit extrapyramidal features, and many PD patients develop dementia Similarly, at autopsy many AD patients not only exhibit the neuropathologic features of that disorder but also exhibit nigral pathology, including Lewy bodies. The vast majority of demented PD patients show widespread neurofibrillary tangles and senile plaques as well as Lewy body formation and nigral degeneration. The extent of such overlap is far greater than one would anticipate by chance alone. We argue that such overlap reflects a common pathogenic mechanism for the neurodegeneration encountered within specific vulnerable neuronal populations. Furthermore, we suggest that the current nosologic approach, which attempts to separate AD from PD, fails to properly deal with the issue of overlap and that a new classification of the neurodegenerative disorders should be considered.</div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Perl, D P" sort="Perl, D P" uniqKey="Perl D" first="D. P." last="Perl">D. P. Perl</name></noRegion><name sortKey="Olanow, C W" sort="Olanow, C W" uniqKey="Olanow C" first="C. W." last="Olanow">C. W. Olanow</name></country><country name="Canada"><noRegion><name sortKey="Calne, D" sort="Calne, D" uniqKey="Calne D" first="D." last="Calne">D. Calne</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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